Mechanistic and therapeutic insights gained from studying rareskeletal diseases
Authors: Dr. Laura Tosi and Dr. Matthew Warman
Evaluation of the severity of malocclusions in children
affected by osteogenesis imperfecta with the peer assessment rating and
Published in the American Journal of Orthodontics and
Dentofacial Orthopedics. March 2013.
Authors: Rizkallah J, Schwartz S, Rauch F, Glorieux F, Vu
DD, Muller K, Retrouvey JM.
Source: Montreal Children's Hospital-McGill University,
Montreal, Quebec, Canada
INTRODUCTION: Osteogenesis imperfecta is a heritable
disorder affecting bone and tooth development. Malocclusion is frequent in
those affected by osteogenesis imperfecta, but this has not been studied in
detail. The purpose of this study was to describe and quantify the severity of
malocclusions in patients with osteogenesis imperfecta.
METHODS: Articulated dental casts were obtained from 49
patients diagnosed with osteogenesis imperfecta (ages 5-19 years; 28 female)
and 49 age- and sex-matched control subjects who did not have osteogenesis
imperfecta. Both groups were seeking orthodontic treatment. Malocclusions were
scored by using the peer assessment rating (PAR) and the discrepancy index
RESULTS: The average United Kingdom weighted PAR scores were
31.1 (SD, 14.5) for the osteogenesis imperfecta group and 22.7 (SD, 10.7) for
the control group (P <0.05). The mean United States weighted PAR scores were
32.2 (SD, 15.0) for patients with osteogenesis imperfecta and 21.6 (SD, 9.6)
for the controls (P <0.05). The average modified DI scores were 29.8 (SD,
20.2) for the osteogenesis imperfecta group and 12.4 (SD, 6.8) for the control
group (P <0.05). Group differences were greatest for lateral open bite
(osteogenesis imperfecta group, 7.1; control group, 0.3) for the DI parameters
and anterior crossbite (osteogenesis imperfecta group, 13.0; control group, 3.8
[United Kingdom]) for the PAR.
CONCLUSIONS: Both the PAR and the DI showed that
malocclusions were significantly more severe in patients with osteogenesis
imperfecta than in the control group. There was a higher incidence of Class III
malocclusion associated with anterior and lateral open bites in patients
affected by osteogenesis imperfecta.
Copyright © 2013 American Association of Orthodontists.
Published by Mosby, Inc. All rights reserved.
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