The OI Foundation has been supporting research efforts for 36 years...

A Summary of the Foundation's Research Efforts:


  • Second OI Symposium for physicians and researchers is held at Shriners in Chicago.
  • Biochemical abnormalities in collagen production by people with OI are identified.
  • Fluoride is abandoned as a treatment for OI.


  • OI is discovered to be caused by abnormalities in Type I collagen.


  • First international OI meeting is held in Cherry Hill, NJ with representatives from OI
    societies in Scotland, Australia, America, and Washington, DC.
  • David Sillence publishes OI Type Classification (OI Foundation funded).


  • Skin biopsy test for OI is used in research.
  • Publication of Clinical Orthopaedics volume is dedicated to OI treatment and research, edited by Dr. Edward Millar and Dr. James Albright, OI Foundation Medical Advisory Council members.


  • Third OI Symposium for physicians and researchers is held at Shriners in Chicago.
  • Michael Geisman Research Fellowship is established.
  • First human type I collagen gene is cloned.
  • Calcitonin is abandoned as a treatment for OI.First sequence characterization of the Type I collagen mRNA genes takes place.


  • Second International OI meeting is held in Scotland.


  • MOV mouse is generated (Jaenish).


  • Mosaicism identified as the cause for OI inheritance (not autosomal recessive
  • Mutation in Type I collagen gene with OI is identified.


  • Growth hormone therapy research begins.


  • The first prenatal diagnosis of OI is performed, based on the gene marker for Type I collagen, performed during chorionic villius sampling (CVS) or ultrasound.


  • Third International Conference on OI is held in Italy.


  • Mini-gene mouse is generated by Darwin Prockop, M.D., member of the OI Foundation (MAC).


  • New Frontiers in OI Research meeting is held at NIH.


  • The OIM mouse with the OI mutation is described


  • 8th International OI conference is held in Baltimore, MD, 18 countries are represented.


  • 9th International OI conference is held, with 16 countries represented.


  • The DNA test for type I collagen gene abnormality is available.
  • Over 200 mutations in Type I collagen are identified


  • An observational study of bisphosphonate treatment in 30 children with OI is


  • International OI Conference is held, 21 countries are represented.
  • New Research Strategies in OI scientific meeting is held at NIH.
  • The Brtl mouse model for OI is generated by Joan Marini, M.D., Ph.D., member
    of the OI Foundation MAC.


  • Following the previous New Research Strategies in Osteogenesis Imperfecta
    scientific meeting held in 1999, the pace of research accelerated dramatically with
    approval by the National Institute of Arthritis and Musculoskeletal and Skin Diseases
    (NIAMS) of five projects totaling more than $1.6 million dollars. Four of those five new
    grantees were in attendance to share their progress.
  • Thirty-nine researchers from laboratories throughout the USA, plus key investigators
    from Canada and Ireland were invited to come to Chicago, IL and share their knowledge,
    results and current research questions. More than 20% of the researchers received OI
    Foundation funding during their early careers and almost a third of those present are
    members of the OI Foundation's prestigious Medical Advisory Council.


  • The first scientific meeting in 1999 resulted in an NIH commitment to fund
    over $10 million in OI research over 5 years. The second scientific meeting in 2001
    expanded its scope with international participants and experts from other fields sharing
    successful models for gene therapy. This third scientific meeting in 2003 expanded on the two
    previous meetings - literally, by expanding from one day to two, and topically, by
    covering new clinical treatment data for the first time.


  • Dr. Wenstrup reported that a review of the 16 OI Foundation grants awarded
    between 1999 and 2002 showed that two of the researchers have received additional
  • A scientific meeting entitled Mild OI - toward better understanding and treatment is conducted in April, 2004.
  • This meeting also strengthened the partnership between the Children's Brittle Bone
    Foundation, the OI Foundation and the research community. In addition to the scientific
    dialogue, the meeting served as an opportunity to plan for a proposed multi-site network
    of clinical research centers that will facilitate translation of basic laboratory science into
    standardized therapies for OI, improve diagnosis and train medical professionals. This
    helped participants focus on collaborative activities that would be part of a Center, such
    as developing a standard list of comparison data to obtain from all patients.


  • International OI Conference United States-41 countries represented
  • Linked Clinical Research Center phase I planning process begins


  • New Research and Clinical Strategies in Osteogenesis Imperfecta Scientific Meeting, Chicago , IL
  • OI Registry opens
  • Linked Clinical Research Center phase II planning process begins


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